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7-Ketodehydroepiandrosterone (7-keto-DHEA), also known as 7-oxoprasterone, is a steroid produced by metabolism of the prohormone dehydroepiandrosterone (DHEA). 7-Keto-DHEA is not directly converted to testosterone or estrogen, and has thus been investigated as a potentially more useful relative of DHEA. It is often used as the acetate ester prodrug 7-keto-DHEA acetate.
While in vitro and animal studies have suggested potential uses for 7-keto-DHEA in humans, there is currently limited scientific evidence to support its use as a weight-loss aid, muscle-builder, immune stimulant, or for any other clinical use. One randomized, placebo-controlled research study on dieting and exercising healthy overweight individuals found 7-keto-DHEA significantly increased body-weight loss and fat-loss. 7-Keto-DHEA is marketed as a dietary supplement with the implication that it may accelerate weight loss, increase metabolism, enhance memory, or prevent age-related changes. When used in a topical (skin lotion) product 7-keto-DHEA caused long-lasting changes in the body’s levels of testosterone, epitestosterone, estradiol, and other steroid hormones. Researchers have raised concern that supplements may trigger positive tests for performance-enhancing drugs.
The World Anti-Doping Agency lists 7-keto-DHEA as a prohibited anabolic agent.
7-Keto-DHEA is under development for the treatment of post-traumatic stress disorder (PTSD).

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